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Naltrexone and bupropion are combined in a single medication called Contrave, primarily used for weight management in individuals who are overweight or obese. Naltrexone is an opioid receptor antagonist that helps reduce food cravings, while bupropion is an antidepressant that can also suppress appetite and increase energy expenditure. The combination of these medications is thought to work synergistically to help promote weight loss. Contrave is typically used alongside a reduced-calorie diet and increased physical activity to achieve and maintain weight loss goals. It should be used under medical supervision due to potential side effects and interactions with other medications.

Naltrexone is a medication primarily used in the treatment of opioid dependence and alcohol use disorder. It works by blocking the effects of opioids and alcohol in the brain, reducing cravings and preventing relapse. Naltrexone is available in both oral and extended-release injectable formulations. Additionally, low-dose naltrexone (LDN) is sometimes used off-label for conditions such as autoimmune diseases, chronic pain, and fibromyalgia. Naltrexone should be used under medical supervision, and its effectiveness may vary depending on individual circumstances and adherence to treatment.